Skin barrier cross-section Cross-section of the skin on an oilfield worker's hand: skin cells (bricks) sealed by lipid mortar. A harsh solvent cleaner takes the crude off and the mortar with it; moisture escapes and irritants get in. SURFACE · BACK OF THE HAND · ON THE RIG FLOOR PHASE 1 · HEALTHY CROSS-SECTION, NOT TO SCALE Stratum corneum 10–20 layers of flat, dead cells.Your outer barrier. Lipid “mortar” Ceramides, cholesterol, fatty acidsseal the gaps between the bricks. Living epidermis Makes new cells that move up andflatten over about 4 weeks. Dermis Collagen and blood vessels. LEGEND Water Irritants Crude Solvent cleaner

Brick-and-mortar model of the stratum corneum: Elias PM, J Invest Dermatol 1983;80:44s–49s. Exposure: R&R Lotion blog, Protecting Your Skin with Barrier Creams (2023). Illustration for education only.